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Sometimes cholesterol, fat, calcium and other substances in the blood combine and form a build-up (plaque) on the inner walls of blood vessels. This causes them to narrow over time. When this happens it is called atherosclerosis and it’s a condition that may lead to blood clots, heart attack and stroke. 

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You can reduce your risk of developing atherosclerosis and other heart problems by keeping your blood cholesterol within normal limits, which sometimes requires medications.