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Clinical Trials May Offer Hope for Patients with Heart Failure

The Temple Heart & Vascular Institute enrolls numerous patients in clinical trials each year. Learn more about the heart failure related clinical trials that are currently offered at Temple.

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Treatments

At the Temple Advanced Heart Failure and Transplantation Program, you will receive an immediate evaluation and access to an array of diagnostic and therapeutic services as part of a full continuum of care.

Temple’s advanced procedures and therapies include:

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Temple Researchers Uncover Novel Mechanism behind Aldosterone-Induced Heart Damage

When the heart begins to fail, the body does everything in its power to fix the situation. But sometimes, those compensatory mechanisms ultimately do more harm than good. Such is the case with the...
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Research Team Led by Temple's Raj Kishore, PhD, Uses Stem Cell Exosomes to Induce Damaged Mouse Hearts to Repair Themselves Without Stem Cell Risk

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Patient Stories

Gerry's Story

Gerry’s grandfather and father both died of a heart attack in their sixties. Gerry had a heart attack at the same age, and despite getting more advanced treatment, his heart began to fail.
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Elroy's Story

For Elroy, a special moment is reading his granddaughter her favorite story, or getting out on the court to teach his grandsons how to shoot a jump shot. A few years ago, Elroy had a heart attack, then another one. His heart was failing.
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Alicia with her daughter

Alicia's Story

Until she fainted in 2012, Alicia didn’t know she was sick. Feeling tired and out of breath were “normal for me,” says the now 52-year-old single mom. The Glenside resident believed she felt that way because she was overweight and out of shape. She was working 10- to 12-hours daily attending her daughter Shannon’s high school track meets and working part-time on an online MBA degree.
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Clinical Trials

Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs)

Over the last two decades, MCSDs have been developed to augment or supplant failing myocardial performance. This therapy has been used successfully as a bridge to heart transplantation, a bridge to recovery, and as permanent implantation or "destination therapy" for intractable heart failure. Although heart transplantation offers life-saving therapy for selected patients, its use is limited by a supply of donor organs that currently meets less than one-tenth the need. As a consequence, the number of MCSD implantations has increased in recent years.
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Sentus QP - Extended CRT Evaluation With Quadripolar Left Ventricular Leads (QP ExCELs)

The QP ExCELs study is designed to confirm safety and efficacy of the BIOTRONIK Sentus OTW QP left ventricular leads to satisfy FDA requirements for regulatory approval of the leads in the US. ...
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Genomic Response Analysis of Heart Failure Therapy in African Americans (GRAHF-2)

The response to therapy with a fixed dose combination of isosorbide dinitrate and hydralazine (FDC I/H) is enhanced in African Americans with heart failure and reduced ejection fraction (HFrEF) when...
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